Medicina Alternativă: fiziologie clinică şi metode de tratament 2010; Vol. 15: 45-52


Morpho-functional state of the cerebellum in diseases accompanied by cognitive and affective disorders

V. Lacusta, A. Litovcenco, A. Gilea, V. Ceres

We systematized the literature data (87 major sources) on the morphological pecularities of the structures of the cerebellum and its functional status in certain diseases involving cognitive-affective disorders (spinocerebellar ataxia, Attention Deficit Disorder with hyperactivity, depression, schizophrenia, autism, cerebellar tumors and infarction). The results of studies that argue in favor of emergence of dissociation of cognitive and emotional functions in patients with lesions of the cerebellum (disconectivity syndrome) are given. Based on the large amount of material obtained by use of neuroimaging techniques, and results of meta-analysis, the role of various structures of the cerebellum in the pathogenesis of diseases associated with cognitive and affective disorders has been discussed. Of particular importance are morphological changes in various structures of the cerebellum (hypoplasia / hyperplasia, atrophy, etc.). The results of our studies showed that children aged 6-14 years with tumors of the cerebellum have different psychoemotional disorders (pessimism about 36,1% of cases, fear, anxiety in 61,1%, disturbance of control of mental activity in 80,6%, clinically significant levels of neuroticism in 86,1%). Among patients with cerebellar infarction, several groups can be distinguished depending on the structure of disorders (subclinical, polymorphic, pseudofrontal).

cerebellum, spinocerebellar ataxia, depression, schizophrenia, autism, cerebellar tumors, infarction of the cerebellum